Why is LCIS Important—Pathological Review

Abstract Purpose of Review Lobular carcinoma in situ (LCIS) encompasses classical LCIS and other rarer more recently recognised variants, namely pleomorphic (PLCIS) florid LCIS. Each those entities has characteristic histological diagnostic criteria, different rates underestimation malignancy recommended management. In addition, lesions can mimic a number benign malignant breast particularly be mistaken for ductal (DCIS). Accurate diagnosis is critical to ensuring the appropriate patient Recent Findings Several international guidelines refining pathological classification, staging management have been updated. This review will provide an up-to-date overview current knowledge with emphasis on multidisciplinary implications. Summary Close correlation between imaging pathology pathway essential Classical core biopsy/vacuum-assisted biopsy (VAB) coded as B3 and, if without discordant imaging, should further sampled by vacuum-assisted excision (VAE). PLCIS managed per high-grade DCIS. Florid rare entity that thought aggressive than Excision clear margin advised.